A particular kind of cannabinoid derived from the cannabis plant is cannabigerol (CBG). It is frequently described as the originator of all cannabinoids. This is due to the fact that other cannabinoids are formed from the acidic version of CBG called cannabigerolic acid (CBGA).
Tetrahydrocannabinol (THC) and cannabidiol (CBD) are two additional more popular cannabinoids derived from cannabis plants (THC).
Compared to other cannabinoids, CBG is present in cannabis plants in lesser amounts. Only 1% of CBG can be found in most strains of the plant, compared to 20 to 25% of CBD or 25 to 30% of THC.
Because of this, cannabinoid-derived consumer goods are uncommon and frequently expensive. However, because of the numerous potential advantages that cannabis has to offer, CBG is becoming more and more popular.
How to Make CBG
Young cannabis plants are used to make CBG because they have higher concentrations of the compound than mature plants do..
Cannabis strains with a higher CBG content than others include White CBG, Super Glue CBG, and Jack Frost CBG. These strains are specifically bred to yield more CBG, according to their cultivation.
CBGA, an acidic version of CBG, is the precursor of both CBD and THC. Because of this, cannabis plants that are younger have greater CBG levels.
You’ll discover very modest quantities of CBG in fully developed plants with significant levels of THC and CBD. This occurs because while the plant grew, the majority of the CBG was already changed into CBD and THC.
Cannabis farmers have been experimenting with cross-breeding and genetic modification to aid cannabis plants in producing more CBG due to the difficulties in obtaining CBG.
How CBG Operates
The body’s endocannabinoid system breaks down CBG. No matter what is happening in our surroundings outside, the endocannabinoid system in our bodies, which is made up of chemicals and receptors, is in charge of maintaining our bodies functioning at their bes
In our bodies, CBG mimics the endocannabinoids that our bodies naturally produce.
Body’s Cannabinoid Receptors
CB1 and CB2 cannabinoid receptors are present in our body. While CB2 receptors are found in the immune system and other parts of the body, CB1 receptors are found in the neurological system and brain.
CBG functions by attaching to both receptors, where it is hypothesized to enhance the action of anandamide, a neurotransmitter involved in improving motivation and pleasure, controlling food and sleep, and reducing pain. You won’t get high from CBG because it doesn’t have any psychotropic effects like THC does.
Possible advantages of CBG
Similar to CBD, CBG has been used to treat pain without having the same high that comes from THC or other cannabinoids.
According to research, CBG can potentially be medicinal. There aren’t many human studies on this, though, and more work has to be done.
The following therapeutic advantages of CBG are described below, according to some encouraging animal research.
Infloammatory Bowel Disease (IBD)
Inflammatory bowel disease is a condition that causes chronic inflammation in the gut. Millions of individuals around the world are impacted by it, and it is incurable.
In 2013, an experimental animal study looked at the impact of CBG on inflammatory bowel disease.
In the colons of mice, researchers created inflammations resembling IBD before administering CBG. Nitric oxide production and inflammation were found to be decreased by CBG. Reactive oxygen species (ROS) were also produced less frequently in the intestines. They came to the conclusion that CBG ought to be taken into account for clinical research with IBD patients.
Researchers discovered that CBG has therapeutic promise for the treatment of glaucoma in an animal investigation.
Researchers observed a decrease in eye pressure and a rise in aqueous humor outflow, a fluid generated by the eye that controls eye pressure and feeds the eye, after giving CBG to cats with glaucoma.
In the brain, nerve cells die down as a result of Huntington’s disease. 2015 research looked at mice with an experimental form of Huntington’s disease to see if CBG and other cannabinoids had any neuroprotective effects.
It was discovered that CBG functions as a neuroprotectant, shielding the brain’s nerve cells from harm. Additionally, it reduces the symptoms of motor deficits and protects striatal neurons from 3-nitropropionic acid toxicity.
CBG possesses antibacterial qualities, according to a study conducted in 2020 on the antimicrobial potential of cannabis. specifically against methicillin-resistant strains of the staph infection-causing bacterium Staphylococcus aureus (MRSA) 5.
Battling cancerous cells
In a 2014 study, scientists looked at how CBG affected rats that had colon cancer. They discovered that CBG demonstrated some promise in preventing the growth of colorectal cancer cells and blocking the receptors that promote cancer cell growth.
They recommended that the treatment and prevention of colon cancer should take into account the usage of CBG.
CBG is most frequently manufactured as oil for consumer consumption. By taking pure CBG oil, you can benefit from CBG. CBG oils, however, are scarce and expensive.
The good news is that consuming Full spectrum CBG oils can help you reap some of the advantages of CBG. Full spectrum CBD oils contain all the cannabinoids contained in a cannabis plant, including CBG.
The entourage effect is a phenomena that occurs when cannabinoids are used in conjunction with one another.
CBD versus CBG
Because of their similar actions on the endocannabinoid system and numerous other similarities, CBG and CBD are frequently compared.
Since CBG and CBD are not psychoactive, they will not have the same effects on your mood as THC.
However, if you consume a cannabis plant, they can lessen THC’s psychoactive effects. The quantity that is present in the majority of cannabis plants is one of the main distinctions between CBD and CBG. The majority of cannabis plants only have 1% CBG but up to 25% CBD.
Compared to CBD, CBG has a different effect on our endocannabinoid system. CBG may be more effective at providing its benefits to our systems because it binds directly to both CB1 and CB2 receptors.
Scarcity of CBG
Due to its challenging manufacture, CBG is extremely rare. Compared to other cannabinoids like THC and CBD, it’s far more difficult to generate. Since CBG and CBD are quite similar, producers would rather create CBD.
Products made from CBG are quite expensive when it is created. However, CBG has a number of exciting potential advantages, and further study is being done to make the cannabinoid more readily produced and available.