10-OH-HHC is a hydroxy derivative of hexahydrocannabinol (HHC), which is a trace cannabinoid found in cannabis plants and a metabolite of tetrahydrocannabinol (THC). 10-OH-HHC is one of the possible products of the oxidation of HHC by cytochrome P450 enzymes in the liver. However, 10-OH-HHC is not very stable and can be further metabolized to 10-carboxy-HHC, which is inactive. Therefore, 10-OH-HHC has a low bioavailability and a short half-life in the body.
Effects of 10-OH-HHC
The effects of 10-OH-HHC are not well studied, but it is likely to have some cannabimimetic activity, meaning it can mimic the effects of THC and other cannabinoids. However, the potency and selectivity of 10-OH-HHC for the cannabinoid receptors CB1 and CB2 are unknown. It is possible that 10-OH-HHC has different effects depending on the route of administration, as oral ingestion may result in more conversion to 10-carboxy-HHC than inhalation or sublingual absorption.