8-OH-HHC, as a primary metabolite of hexahydrocannabinol (HHC), holds a significant place in the research and understanding of cannabinoid interactions and effects . Here’s a more detailed look into 8-OH-HHC and its importance.
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- Primary Metabolite of HHC: 8-OH-HHC is an active primary metabolite formed when HHC is metabolized in animals. This makes it a crucial component in the study of HHC’s effects and toxicology.
- Metabolism Process: Like Δ9-THC and Δ8-THC, HHC undergoes metabolism via cytochrome p450 enzymes (CYP3A4, CYP2C9, and CYP2C19). This process leads to the production of several oxygenated derivatives, including 8-OH-HHC.
- 8-OH-HHC vs. Other Metabolites: While 11-OH-HHC is a major metabolite and is quickly oxidized to an inactive form (11-COOH-HHC), the oxidation of 8-OH-HHC leads to 8-oxo derivatives. These derivatives are then conjugated and excreted, showcasing a distinct metabolic pathway.
This comprehensive look into 8-OH-HHC aprovides insight into its significance, usage, and safety considerations. It’s important to always comply with legal and safety guidelines when using such products.