One of the 150 phytocannabinoids found in cannabis and hemp plants is delta-9 tetrahydrocannabutol (delta-9 THCB). Like many other recently identified phytocannabinoids, it is present in these plants but only in very minute amounts.
How to describe Delta 9 THCB?
THCB functions similarly to THC through CB1 and CB2 receptors, which are present in our brains, central nervous system, immune cells, spleen, and other organs. But when compared to Delta 9-THC, Delta 9-THCB binds to CB1 receptors with a higher affinity. In comparison to Delta 9-THC, it has a higher affinity, which implies that it binds to the CB1 receptors more effectively. It is yet unclear how these affinities relate to the precise mechanisms through which the effects take place. While its homolog Delta 9-THCB is 13 times more active with the CB1 receptor when compared to Delta 9-THC, Delta 9-THCP is 33 times more active than Delta 9-THC. This suggests that because Delta 9-THCB binds to CB1 more readily than conventional Delta 9-THC, it may have greater potency than Delta 9-THC. In fact, this might change, though, as Delta 9-THCB binds to a different region of the receptor.
An analytical reference standard known as 9-THCB is classified as a phytocannabinoid. This item is designed for forensic and research purposes.
Unfortunately, there has only been one pre-clinical study on the butyl homolog of delta-9-THC.
To determine whether THCB possessed any painkilling and anti-inflammatory qualities, an in vivo test was conducted.
According to this mouse study, THCB and regular Delta 9-THC had comparable effects. The study specifically highlighted the possibility of THCB’s anti-inflammatory and pain-relieving effects.
Apart from its possible agonistic activity toward the CB1 and CB2 receptors, THCB has minimal study or background information. However, this binding activity can indicate a stronger THC than usual.
D9 THCB Advantages
Although there is less data available, as mentioned above, scientists have shown that it has a comparable physiological effect to Delta 9-THC.
The results of the completed animal studies indicate potential for analgesic and anti-inflammatory actions.
Despite this affinity, where Delta 9-THCB attaches to the CB1 receptors more readily, there is insufficient proof to say if it causes intoxication.
But because it more readily attaches to CB1 receptors, it is thought to have more intense psychoactive effects than Delta 9-THC. Studies on humans are required to ascertain any immediate or long-term effects of Delta 9-THCB.
Your Supplier of Delta-9 THCB
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- Smith, R.M. Identification of butyl cannabinoids in marijuana. J. Forensic Sci. 42(4), 610-618 (1997).
- Harvey, D.J. Characterization of the butyl homologues of Δ1-tetrahydrocannabinol, cannabinol and cannabidiol in samples of cannabis by combined gas chromatography and mass spectrometry. J. Pharm. Pharmacol. 28(4), 280-285 (1976).
- Linciano, P., Citti, C., Luongo, L., et al. Isolation of a high-affinity cannabinoid for the human CB1 receptor from a medicinal Cannabis sativa variety: Δ9-Tetrahydrocannabutol, the butyl homologue of Δ9-tetrahydrocannabinol. J. Nat. Prod. 83(1), 88-98 (2019).